UWorld Endocrine Test 2025 – 400 Free Practice Questions to Pass the Exam

Glucagon plays a crucial role in glucose metabolism by stimulating glucose production in the liver. When blood glucose levels are low, such as during fasting or intense exercise, glucagon is secreted by the alpha cells of the pancreas. Its primary function is to promote glycogenolysis, which is the breakdown of glycogen into glucose, and gluconeogenesis, the process of creating glucose from non-carbohydrate sources. Both of these actions increase the availability of glucose in the bloodstream, helping to raise blood sugar levels to provide energy for bodily functions.

Given the context of glucose metabolism, glucagon acts as a counter-regulatory hormone to insulin, which facilitates the uptake and storage of glucose. By encouraging glucose production and release into the bloodstream, glucagon ensures that the body maintains adequate energy levels, especially in times of need. This is why stimulating glucose production is the correct and vital role of glucagon in glucose metabolism.